Biomolecular Structures
Up to date schedule information
Core course in MSc Chemistry – Chemical Biology, MSc Life Science and Technology, elective course MSc Chemistry
Admission requirements
BSc in LST or BSc in MST with a major in Chemistry. Others should have knowledge of protein and nucleic acid structure, and of spectroscopy.
Description
The course introduces the students to the methods of structure determination of biomacromolecules: X-ray diffraction of crystals (XRD), Electron Microscopy (EM) and Nuclear Magnetic Resonance (NMR).
At the end of the course students:
have an overview of how structures are determined by XRD, EM and NMR (the physical principles, implementation, raw data, analysis, modelling),
have sufficient background to interpret molecular models in the literature critically on the basis of the standard quality parameters,
can critically evaluate the possibilities and limitations of the various methods
are familiar with the latest developments and insights in the field of structural biology (e.g.
structure determination of minor states by NMR, high resolution cryo-EM).
Mode of instruction
Lectures, computer tutorials and exercises.
Language
English
Timetable
Schedule information can be found on the website of the programmes.
Literature
Papers from the scientific literature
Slides presented during the courses
Internet self study
Exercises
Examination
Assignments (10%) “Open Book” written examination (90%)