In these lectures the BBB will be discussed in relation to drug transport to the brain, particularly with emphasis on the morphology, functionality and regulation of the BBB. Further, BBB functionality will be related to BBB permeability, drug transporters at the BBB and drug metabolism by the BBB. Special attention will be given to the influence of diseases at the BBB. Methods will be discussed to estimate in vitro and in vivo BBB functionality and permeability and a case study will be given to the students to be worked out during and discussed at the end of the course.
Coordinator
Dr. A.G. de Boer
Students
Students of Bio-Pharmaceutical Sciences and Biomedical Sciences
Admittance demands
Theme drug effects (2)
Method of instruction
lectures
Required reading
a handout will be given at the beginning of the Caput Lecture Series
Examination
written exam
minimal amount of students
minimum of 5 students
Time table
From 22 January to 5 March on Thursdays from 9.00 to 12.45 h. See the schedule of the lecture series in the master study guide 2008—2009.
For detailed information, see: Programme Caput Lectures Blood Brain Barrier (will be announced later).
Application
Via e-mail: B.Boer@LACDR.LeidenUniv.NL