Genomic Architecture

Course description Genomic Architecture
Year: 2018-2019
Catalog number: 4313GEA13
Teacher(s):
  • Dr. B. Gravendeel
  • Dr. G.P.H. van Heusden
  • Prof.dr. P.J.J. Hooykaas
  • Prof.dr. J. Memelink
  • Dr. A.F.J. Ram
  • Dr. D.E. Rozen
  • Prof.dr. V. van Noort
  • Dr. K. Vrieling
  • Prof.dr. G.P. van Wezel
Language: English
Blackboard: Yes
EC: 6
Level: 400
Period: Semester 1
  • Yes Elective choice
  • No Contractonderwijs
  • Yes Exchange
  • Yes Study Abroad
  • No Evening course
  • No A la Carte
  • No Honours Class

Admission requirements

BSc degree

Contact

Coordinator: Dr. B. Gravendeel
Email: Barbara.Gravendeel@naturalis.nl

Description

How are we genetically different from Neanderthalers? How many genes do organisms have? What fraction of our genome consists of genes? Do prokaryotes shop for genes? Why do salamanders have much more DNA per cell than we have? How does the genome of related species differ? How is the DNA of different individuals different? How well can one make predictions on health and personalized medicine from your DNA? With the advance of genome sequencing all these questions about DNA and evolution can, in principle, be answered. Starting from the basics (introns, extrons, gene families, recombination, QTLs, sequencing) we address these questions and ask what these new insights mean for ideas about evolution and health of species. In the practical you will solve several genomic puzzles, both at a basic and at an advanced level.

Learning goals:

Course objectives:

  • update knowledge on basic genetic mechanisms
  • overview of field of genomics
  • learn to apply genomic information for answering a suite of scientific questions

Final qualifications:

  • Student is familiar with technical terms used in genomics
  • Student knows how genomes of major groups of organisms are organized
  • Student can use genomic information for answering scientific questions about evolution and health.

Timetable

From 1 October – 26 October 2018. First 3 weeks lectures, self study (DNA, RNA, proteins, genomes throughout the Tree of Life, human evolution) and practicals. Week 4 group projects. The detailed schedule will be placed on Blackboard.

Mode of instruction

Lectures, reading chapters from Lesk (2017) third edition, individual project (last week), presentation.

Assessment method

Three multiple choice tests and presentations of group projects.

Blackboard

Blackboard will be used for communication.

Reading list

Strongly advised to buy as backup for students:

Lesk AM (2017) Introduction to genomics. Oxford UP, third edition

Registration

in Usis and enroll in Blackboard

Exchange and Study Abroad students, please see the Prospective students website for more information on how to apply.

Languages